University of Ottawa creates opportunities for Pharmaceutical Industry

Scientific innovation in the nation’s capital takes aim at the pharmaceutical industry with the development of new and exciting technologies that could create opportunities for pharmaceutical developers and manufacturers.

 

 

 The University of Ottawa’s renown Faculty of Science and a team of world class chemists have taken the task of improving the quality and affordability of pharmaceutical products by developing new tools and techniques for drug development and manufacturing. The technologies disclosed below are products of the synergy between active research programs in natural product synthesis and biosynthesis, medicinal chemistry, bioanalytical chemistry, and chemical biology, which continuously serve to bolster the University’s reputation in the area of biopharmaceutical chemistry.

 Among the new technologies under development is a series of techniques related to carbon-nitrogen chemistry. One application is in the synthesis of amino acids for synthetic protein development, which is an area that will have profound effects on the pharmaceutical industry. The University of Ottawa techniques employ a one step reaction to amino acids and their derivatives, which can be used to cheaply synthesize many peptides required in the manufacturing of protein and peptide based drugs. Further developments in the synthesis of beta-aminocarbonyl, found in several major drugs, have also reduced the number of steps in the synthesis.

 Working in a collaborative environment, the University’s chemistry research is moving from the chemists’ bench, and into disease models. For instance, the chemistry profiled above is currently being used to synthesize Nucleuophilic Enzyme inhibitors. These molecules present new opportunities for pharmaceutical developers to create new cancer fighting drugs based on the inhibitors. Furthermore, the inhibitors can have investigational applications that could be used to discover new pathophysiological processes.

 Another fascinating and potentially ground breaking technology, is a new type of Single Molecule Magnet or SMM that can be used for drug delivery and imaging contrasting. These compounds were created though the University of Ottawa’s globally recognized expertise in photochemistry. The SMMs are easy to produce by combining a gold nanoparticle with a dinuclear dysprosium SMM in a manner that retains their magnetic properties. The technology enables an affordable source of stable SMM to develop materials for a variety of applications in medicine and information technology.

 The technologies listed above are but a fraction of what the University of Ottawa has to offer in terms of partnerships with the pharmaceutical industry. For more information please contact the University of Ottawa’s Technology Transfer and Business Enterprise Office for more details by visiting ttbe.uottawa.ca

 Information on new technologies related to chemistry and pharmaceutical development can be found by clicking on the links for each technology listed below:

 

Amino Acids and Derivatives; One Step Synthesis

 

Efficient synthesis of synthetic peptides containing beta-aminocarbonyls

 

Biaryl coupling to generate compounds for pharmaceutical and organic semiconductor applications

 

Inhibitors of Nucleophilic Enzymes for therapeutic and drug discovery applications

 

Single-Molecule Magnets (SMM) for drug delivery and imaging contrast agents

 

Antioxidants to preserve lipids

 

Non-invasive 3D Imaging using CARS

 

Pharmaceutical Authentication and Monitoring

 

A full list of University of Ottawa technologies can be found at the AUTM Global Technology Portal.

About Ottawa Technology Transfer Network
The Ottawa Technology Transfer Network (OTTN) is a collaboration among academic research institutions affiliated with the University of Ottawa and who's goal is to enhance the economic impact of research commercialization through the sharing of best practices, enhanced market knowledge, student engagement and proactive industrial interation. OTTN members include the University of Ottawa, the Ottawa Hospital Research Institutie (OHRI), the Childrens' Hospital of Eastern Ontario (CHEO) and the Unviversity of Ottawa Heart Institute (UOHI)

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